Clinical and Haematological Effects of Hydroxyurea in β -Thalassemia Intermedia Patients
نویسندگان
چکیده
منابع مشابه
Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea
Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...
متن کاملSide effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia
Background Sickle hemoglobin is the most common abnormal hemoglobin in the United States. Hemoglobin S arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). The presence of fetal hemoglobin (HbF) plays a relatively protective role since a significant amount of HbF interferes with HbS polymerization, the pathogenesis mechanism of ...
متن کاملHypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea
Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...
متن کاملhypothyroidism in β-thalassemia intermedia patients with and without hydroxyurea
hydroxyurea (hu) has been successfully used in patients with β-thalassemia intermedia (β-ti). we aimed to evaluate the effect of the long-term use of hu on thyroid function in patients with β-ti. seventy-five patients with β-ti aged≥11 years and taking hu were randomly selected during 2010 in southern iran. thirty-one patients with β-ti without hu were considered as a control group. serum level...
متن کاملSide effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia
BACKGROUND Sickle hemoglobin is the most common abnormal hemoglobin in the United States. Hemoglobin S arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). The presence of fetal hemoglobin (HbF) plays a relatively protective role since a significant amount of HbF interferes with HbS polymerization, the pathogenesis mechanism of th...
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ژورنال
عنوان ژورنال: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
سال: 2015
ISSN: 2249-782X
DOI: 10.7860/jcdr/2015/14807.6660